Notes on “Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation”

September 30, 2008

Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation: Anton A. Komar, Thierry Lesnik and Claude Reiss.

The gist: The authors performed an experiment which demonstrated the effect of synonymous codon substitutions. They replaced some codons in e. coli with a “more optimal” synonym. The result was increased protein levels due to higher speed of translation, but lower activity, probably due to protein misfolding.

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